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Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Related Experiment Video

Updated: Apr 14, 2026

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Adhesive and sealant interfaces for general surgery applications.

Francesca Scognamiglio1, Andrea Travan1, Isabella Rustighi1

  • 1Department of Life Sciences, University of Trieste, Italy.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|April 21, 2015
PubMed
Summary

Biological adhesives and sealants are crucial for tissue repair and wound closure in surgery. This review covers key polymeric materials, their properties, and future development for surgical applications.

Keywords:
adhesionbiomimeticinterface(s)polymertissue adhesion

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Polymer Chemistry

Background:

  • Biological adhesives and sealants are vital for tissue repair, wound reinforcement, and replacing traditional suturing methods in general surgery.
  • Meeting clinical, biological, and material requirements is essential for effective surgical adhesives and sealants.
  • Polymeric materials, both natural and synthetic, form the basis of these surgical interfaces.

Purpose of the Study:

  • To review major adhesive and sealant materials for general surgery developed over recent decades.
  • To highlight critical factors for selecting appropriate formulations based on adhesion mechanisms, mechanical performance, and body fluid resistance.
  • To identify key aspects for the future development of advanced surgical adhesives and sealants.

Main Methods:

  • Literature review of polymeric materials used in surgical adhesives and sealants.
  • Analysis of adhesion mechanisms, mechanical properties, and biocompatibility of various components.
  • Discussion of natural polymers (fibrin, gelatin, dextran, chitosan) and synthetic polymers (cyanoacrylates, polyethylene glycol, polyurethanes).

Main Results:

  • Key polymeric components include fibrin, gelatin, dextran, chitosan, cyanoacrylates, polyethylene glycol, and polyurethanes.
  • Adhesion mechanisms, mechanical performance, and resistance to body fluids are critical selection criteria.
  • These materials form 3D networks for hemostasis, sealing, or adhesion to tissues.

Conclusions:

  • A comprehensive understanding of material properties is necessary for optimal formulation of surgical adhesives and sealants.
  • Future developments should focus on enhancing adhesion, mechanical strength, and biocompatibility for improved surgical outcomes.
  • The review provides a foundation for selecting and designing next-generation surgical adhesives and sealants.