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Updated: Apr 14, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction
Masaya Kato1, Ryuta Muromoto1, Sumihito Togi1
1Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Abstract:
The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that PML-mediated suppression of IL-6-induced STAT3 activation by disrupting interactions between STAT3 and HDAC3. These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by interacting with HDAC3.
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