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Synthesis and anticancer properties of fucoidan-mimetic glycopolymer coated gold nanoparticles
Mattias Tengdelius1, Deepanjali Gurav, Peter Konradsson
1Division of Organic Chemistry, Linköping University, SE-581 83, Linköping, Sweden.
Chemical Communications (Cambridge, England)
|April 21, 2015
Abstract:
Gold nanoparticles coated with fucoidan-mimetic glycopolymers were synthesized that displayed good colloidal stability and promising anti-cancer properties. Fucoidan mimetic glycopolymers on their own were nontoxic, while glycopolymer coated gold nanoparticles displayed selective cytotoxicity to human colon cancer cell lines (HCT116) while it was non-toxic to mouse fibroblast cells (NIH3T3).
