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Updated: Apr 14, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Reduced default mode network connectivity in schizophrenia patients
Anne Pankow1, Lorenz Deserno2, Martin Walter3
1Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany.
Abstract:
In the present study, we explored possible alterations in the default mode network (DMN) and its functional connectivity in 41 schizophrenia patients and 42 age-matched healthy controls. Schizophrenia patients displayed reduced activation in the ventromedial prefrontal cortex, left superior temporal gyrus including auditory cortex and temporal pole. Psychophysiological interaction analysis revealed reduced connectivity between left superior temporal gyrus including auditory cortex and the left temporal pole in schizophrenia patients compared to healthy subjects.
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