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Formulation development and process parameter optimization of lipid nanoemulsions using an alginate-protein
Surashree Sen Gupta1, Mahua Ghosh1
1Department of Chemical Technology, University College of Science & Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009 India.
Journal of Food Science and Technology
|April 21, 2015
Summary
Stable nanoemulsions were developed for health-beneficial lipids using sodium alginate and calcium caseinate. Optimal conditions involved specific oil:emulsifier ratios, alkaline pH, 50°C, and 100 mM electrolytes for enhanced stability.
Area of Science:
- Food Science and Technology
- Materials Science
- Biochemistry
Background:
- Unstable, health-beneficial lipids require stabilization for effective delivery.
- Nanoemulsions offer a liquid formulation for encapsulating sensitive lipids.
- Developing stable nanoemulsion formulations is crucial for ingredient synthesis.
Purpose of the Study:
- To optimize parameters for creating stable nanoemulsions.
- To investigate the impact of oil:emulsifier ratios on emulsion stability.
- To determine ideal process conditions for lipid nanoencapsulation.
Main Methods:
- Optimization of temperature, pH, and electrolyte concentrations.
- Utilized varying oil:emulsifier ratios (10:1 to 30:1).
- Employed sodium alginate as encapsulant and calcium caseinate as emulsifier.
- Assessed stability using particle-size, zeta-potential, viscosity, and lipid retention analyses.
Main Results:
- Emulsion systems with 15:1 and 10:1 oil:emulsifier ratios demonstrated superior stability and lipid retention.
- The 15:1 ratio was preferred due to reduced emulsifier requirements.
- Optimal conditions identified: alkaline pH, temperature up to 50°C, and electrolyte concentration up to 100 mM.
Conclusions:
- Stable nanoemulsions for health-beneficial lipids can be achieved through careful parameter optimization.
- Calcium caseinate and sodium alginate are effective components for lipid nanoencapsulation.
- The study provides a robust method for producing stable lipid nanoemulsions for various applications.
