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Updated: Apr 14, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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Primary cutaneous and subcutaneous Ewing sarcoma.

Angela Di Giannatale1, Anna Maria Frezza2, Marie-Cécile Le Deley3

  • 1MD, Pediatric and Adolescent Oncology, Gustave Roussy, 114 Rue Eduard Vaillant, 94805, Villejuif, France.

Pediatric Blood & Cancer
|April 21, 2015
PubMed
Summary
This summary is machine-generated.

Primary cutaneous/subcutaneous Ewing sarcoma (scEWS) is rare, predominantly affecting young females. This study found excellent survival rates with appropriate treatment, emphasizing biopsy and molecular analysis at diagnosis.

Keywords:
adolescentcutaneousewing sarcomasubcutaneousyoung adults

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Medical Genetics

Background:

  • Primary cutaneous/subcutaneous Ewing sarcoma (scEWS) is an exceptionally rare tumor.
  • This study details the clinical characteristics, treatment approaches, and outcomes for scEWS patients.

Purpose of the Study:

  • To describe the clinical features, treatment, and outcomes of primary cutaneous/subcutaneous Ewing sarcoma.
  • To evaluate the effectiveness of different treatment modalities for scEWS.

Main Methods:

  • Retrospective analysis of 56 patients diagnosed with scEWS between 1996 and 2012.
  • Review of clinical data, treatment regimens (chemotherapy, surgery, radiotherapy), molecular analyses, and patient outcomes.

Main Results:

  • scEWS predominantly affects young females, with tumors often located on extremities or trunk.
  • Favorable prognostic factors like localized disease and smaller tumor volume were common.
  • Excellent 5-year overall survival (93.8%) and event-free survival (88.5%) were observed.

Conclusions:

  • Avoid unplanned primary surgery to minimize long-term sequelae; prioritize biopsy with molecular analysis and staging.
  • Aggressive treatment is recommended for metastatic scEWS.
  • Further research is needed to determine if less intensive chemotherapy is safe for localized disease to reduce toxicity.