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Incidence and Risk Factors for Urolithiasis in Patients with Crohn's Disease

Min Jung Kim1, Sook-young Woo, Eun Ran Kim

  • 1Department of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Urologia Internationalis
|April 22, 2015
PubMed

Insights

Patients with Crohn's disease (CD) have a 0.7% annual incidence of urolithiasis. Azathioprine/6-mercaptopurine therapy is linked to a reduced risk of developing kidney stones in CD patients.

Area of Science:

  • Gastroenterology
  • Nephrology
  • Urology

Background:

  • Inflammatory bowel disease (IBD) patients may have a higher incidence of urinary tract calculi.
  • Limited data exists on urolithiasis specifically in Crohn's disease (CD) patients.
  • This study investigates urolithiasis incidence and risk factors in CD.

Purpose of the Study:

  • To determine the incidence of urolithiasis in patients with Crohn's disease.
  • To identify risk factors associated with urolithiasis in CD patients.

Main Methods:

  • Retrospective analysis of 387 CD patients from July 2011 to June 2013.
  • Calculi diagnosis via radiologic findings, urinary colic symptoms, or treatment history.
  • Analysis of demographic, phenotypic, medication, and surgical history variables.

Main Results:

  • 18 patients (4.7%) developed urolithiasis post-CD diagnosis.
  • The incidence rate of urolithiasis in CD was 706 per 100,000 patient-years.
  • Azathioprine/6-mercaptopurine treatment showed a negative association with urolithiasis (HR=0.963, p=0.030).

Conclusions:

  • The annual incidence of urolithiasis in CD patients is approximately 0.7%.
  • Azathioprine/6-mercaptopurine therapy appears to be associated with a lower risk of urolithiasis in this population.
Abstract

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