[Eosinophilic fasciitis]

Area of Science:

• Connective tissue diseases
• Rheumatology
• Dermatology

Background:

• Eosinophilic fasciitis (EF) is a rare connective tissue disease.
• It presents as a scleroderma-like syndrome with skin and fascial fibrosis.
• The etiology and pathogenesis remain unclear, with rare visceral involvement.

Purpose of the Study:

• To summarize current knowledge on eosinophilic fasciitis.
• To highlight diagnostic criteria and differential diagnoses.
• To review treatment options and prognosis.

Main Methods:

• Literature review of current knowledge on eosinophilic fasciitis.
• Summary of diagnostic features, including histopathology and laboratory findings (peripheral blood eosinophilia).
• Overview of differential diagnoses and therapeutic strategies.

Main Results:

• Eosinophilic fasciitis is characterized by fibrosis of skin and subcutaneous tissues, and fascia.
• Peripheral blood eosinophilia is a key laboratory finding.
• Effective treatments include corticosteroids, immunosuppressants, dapsone, infliximab, and rituximab.

Conclusions:

• Eosinophilic fasciitis requires careful differential diagnosis from other scleroderma-like conditions.
• Histopathological examination is crucial for definitive diagnosis.
• While prognosis is generally good, long-term treatment may be necessary.