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Targeting the hypoxia pathway to treat pancreatic cancer
Lori A Erickson1, W Edward Highsmith1, Peiwen Fei2
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Abstract:
The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao's research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.
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