Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

2.5K
2.5K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

484
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
484
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

42.1K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
42.1K
Management of Insomnia01:19

Management of Insomnia

801
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
801
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Buttheaded Editor: On Your Cover Letter to the Journal.

Journal of biological rhythms·2026
Same author

On Fealty and Fencers in Science.

Journal of biological rhythms·2026
Same author

Fetoplacental Circadian Rhythms Develop and Then Synchronize to the Mother In Utero.

Journal of biological rhythms·2026
Same author

Simplifying Daily Cortisol Cycle Analysis: Validation and Benchmarking of the Cortisol Sine Score Against Cosinor and JTK_CYCLE models.

medRxiv : the preprint server for health sciences·2026
Same author

Associations of Sleep and Shift Work With Osteoarthritis Risk.

Arthritis care & research·2026
Same author

Set it and forget it: Engineered cells for drug delivery.

Cell systems·2025

Related Experiment Video

Updated: Apr 14, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K

Circadian rhythms: to sync or not to sync.

Cristina Mazuski1, Erik D Herzog1

  • 1Department of Biology, Washington University, St. Louis, MO 63130, USA.

Current Biology : CB
|April 22, 2015
PubMed
Summary

A light pulse temporarily disrupts the daily rhythm of fly brain clock neurons. These neurons then re-establish a synchronized circadian gene expression pattern.

Area of Science:

  • Neuroscience
  • Chronobiology
  • Genetics

Background:

  • Circadian rhythms are endogenous biological processes that regulate daily cycles.
  • Clock neurons in the brain are crucial for maintaining these rhythms.
  • Understanding how external stimuli affect circadian rhythms is vital.

Purpose of the Study:

  • To investigate the real-time response of circadian gene expression in clock neurons to a light stimulus.
  • To elucidate the dynamic changes in neuronal synchronization following a light pulse.

Main Methods:

  • Utilized real-time imaging techniques to monitor circadian gene expression.
  • Observed the behavior of clock neurons in the fly brain following a controlled light pulse.

Main Results:

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.0K
Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

22.3K

Related Experiment Videos

Last Updated: Apr 14, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.0K
Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

22.3K
  • A single light pulse caused a transient desynchronization among clock neurons.
  • Following the disruption, clock neurons successfully re-established a synchronized daily rhythm.
  • Demonstrated the plasticity of the circadian system in response to environmental cues.

Conclusions:

  • Circadian gene expression in clock neurons is sensitive to light stimuli.
  • The fly brain's circadian network exhibits resilience, capable of re-synchronization after perturbation.
  • This study provides insights into the mechanisms governing circadian rhythm stability.