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IL-6 significantly correlates with p-STAT3 expression and presents high variceal bleeding with mortality in cirrhotic

Jung-Ta Kao1, Cheng-Ju Yu2, Chun-Lung Feng2

  • 1School of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; Division of Hepato-Gastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|April 23, 2015
PubMed

Insights

Interleukin-6 (IL-6) over-expression in cirrhotic patients is linked to poor liver function, increased mortality, and correlates with p-STAT3 expression. This finding highlights IL-6 as a key biomarker in liver cirrhosis progression.

Area of Science:

  • Hepatology
  • Biomarkers
  • Inflammation

Background:

  • Mediators like IL-6, IL-27, TNF-α, and VEGF regulate inflammation and angiogenesis.
  • Limited data exists on the correlation between these mediators and STAT proteins in cirrhotic patients.

Purpose of the Study:

  • To investigate the correlation among plasma mediators (IL-6, IL-27, TNF-α, VEGF) and STAT proteins in patients with liver cirrhosis.
  • To assess the clinical significance of these mediators in liver cirrhosis.

Main Methods:

  • Plasma samples from 158 cirrhotic patients and 144 non-cirrhotic individuals were analyzed.
  • Liver tissue immunostaining for p-STAT1 and p-STAT3 was performed on paired samples.
  • Mediator levels were correlated with clinical-pathologic features and patient outcomes.

Main Results:

  • While IL-6, IL-27, TNF-α, and VEGF were elevated in chronic hepatitis and viral hepatitis patients compared to healthy individuals, IL-6 showed the strongest correlation in cirrhotic patients.
  • Over-expressed IL-6 was significantly associated with poorer liver function, increased variceal severity, bleeding, and mortality.
  • Plasma IL-6 strongly correlated with p-STAT3 expression in liver tissues of cirrhotic patients.

Conclusions:

  • Elevated IL-6 levels in cirrhotic patients indicate hepatic dysfunction, variceal bleeding, and increased mortality.
  • IL-6 expression correlates with p-STAT3 activation in the liver, suggesting a role in cirrhosis pathogenesis.
Abstract

Keywords:
Cirrhotic patientsHBV/HCV infectionIL-6p-STAT3

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