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Histrelin for central precocious puberty-a single surgeon experience.
Shannon Rosati1, Rami Maarouf1, Karen Brown2
1Virginia Commonwealth University Health System, Division of Pediatric Surgery, Department of General Surgery, Children's Hospital of Richmond, Richmond, Virginia.
The Journal of Surgical Research
|April 23, 2015
Summary
The histrelin implant offers a safe and effective alternative to injections for treating central precocious puberty (CPP). This method provides continuous hormone release for over a year, with high patient satisfaction and no reported complications.
Area of Science:
- Pediatric Endocrinology
- Reproductive Medicine
Background:
- Idiopathic central precocious puberty (CPP) is commonly treated with monthly injections.
- Histrelin acetate subcutaneous implants offer an alternative, providing continuous release for over a year.
Purpose of the Study:
- To review a single surgeon's experience with histrelin implants for CPP treatment.
- To assess patient and parent satisfaction with the histrelin implant therapy.
Main Methods:
- Retrospective chart review of children who received at least one histrelin implant.
- Patient satisfaction assessed via telephone interviews with parents.
Main Results:
- Fifty-eight children (average age 8.4 years) were treated with histrelin implants for CPP.
- Parents of 44 patients reported high satisfaction with the histrelin implant treatment.
- Implant placement, replacement, and removal were uncomplicated.
Conclusions:
- Histrelin subcutaneous implants are a safe and effective treatment for central precocious puberty.
- The implant offers a convenient and well-tolerated alternative to traditional injection therapies.
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