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Hypersomnolence in Wilson Disease.

Valerie C Amann1,2, Neal K Maru3, Vivek Jain4

  • 1George Washington University, Washington, DC.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|April 24, 2015
PubMed
Summary

Wilson disease (WD), a copper metabolism disorder, is linked to sleep problems, including rare cases of daytime hypersomnolence. Objective testing confirmed sleepiness, suggesting improved patient quality of life with better sleep disorder management.

Keywords:
Wilson diseaseexcessive daytime sleepinesshypersomnolencesleep disturbance

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Area of Science:

  • Neurology
  • Genetics
  • Sleep Medicine

Background:

  • Wilson disease is an inherited disorder of copper metabolism causing organ accumulation.
  • Hepatic, neurologic, and psychiatric symptoms are common, but sleep issues are often overlooked.
  • Daytime hypersomnolence is a rarely reported symptom in Wilson disease patients.

Observation:

  • This report details a case of Wilson disease presenting with hypersomnolence.
  • The patient's excessive daytime sleepiness was objectively confirmed using a multiple sleep latency test (MSLT).

Findings:

  • Wilson disease can be associated with significant sleep disturbances.
  • Hypersomnolence, confirmed by MSLT, is a potential manifestation of Wilson disease.

Implications:

  • Increased awareness and assessment of sleep disorders in Wilson disease are crucial.
  • Addressing sleep issues, particularly daytime sleepiness, may enhance patients' overall quality of life.
  • Further research into the WD-sleep disorder connection is warranted.