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Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus
Sule Yesil1, Ceyhun Bozkurt2, Hikmet Gülsah Tanyildiz2
1Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey syesil2003@yahoo.com.
Objective:
To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation.
Methods:
Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m2 per dose, administered orally, twice daily at approximately 12-hour intervals.
Results:
After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved.
Conclusion:
This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.
