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Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Drugs Used in Upper Respiratory Disorders: Overview01:16

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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Related Experiment Video

Updated: Apr 14, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
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Sublingual Immunotherapy for Allergic Fungal Sinusitis.

Jonathan M Melzer1, Brent R Driskill2, Timothy L Clenney2

  • 1Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center Portsmouth, Portsmouth, VA, USA jonathan.m.melzer.mil@mail.mil.

The Annals of Otology, Rhinology, and Laryngology
|April 24, 2015
PubMed
Summary

Sublingual immunotherapy (SLIT) shows promise for allergic fungal sinusitis (AFS). This study found SLIT to be a safe and effective adjunctive treatment, improving patient outcomes and reducing symptoms in AFS cases.

Keywords:
AFSSCITSLITallergicallergyfungalimmunotherapyrhinosinusitissinusitissublingual

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Area of Science:

  • Otolaryngology
  • Allergy Immunology
  • Medical Mycology

Background:

  • Allergic fungal sinusitis (AFS) involves chronic sinonasal inflammation due to fungal exposure.
  • Standard treatments often fail, leading to high recurrence rates.
  • Subcutaneous immunotherapy (SCIT) is an established adjuvant therapy for AFS.

Purpose of the Study:

  • To evaluate the safety and efficacy of sublingual immunotherapy (SLIT) as an adjunctive treatment for allergic fungal sinusitis (AFS).
  • To assess SLIT's impact on patient symptoms, fungal allergen sensitization, and relevant clinical markers.

Main Methods:

  • A retrospective record review of ten patients diagnosed with AFS treated with SLIT between 2007 and 2011.
  • Analysis of changes in serum IgE levels, subjective symptom complaints, physical exam findings, and Lund-McKay scores.

Main Results:

  • No adverse effects were reported with SLIT therapy in the studied AFS patients.
  • Observed improvements included reduced subjective complaints, better exam findings, lower Lund-McKay scores, and decreased serum IgE levels.
  • The study suggests a potential decrease in sensitization to fungal allergens.

Conclusions:

  • Sublingual immunotherapy (SLIT) appears to be a safe and potentially effective adjunctive therapy for managing allergic fungal sinusitis (AFS).
  • SLIT may offer improved patient outcomes in AFS management.
  • Further research is warranted to confirm these findings.