Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sustained release isoniazid tablets. I--Formulation and in vitro evaluation.

F Bulut-Oner1, Y Capan, S Kas

  • 1Pharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.

Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1989
PubMed
Summary

This study developed sustained-release isoniazid (INH) tablets to improve tuberculosis treatment. Carbomer matrix tablets demonstrated the best sustained release of INH, offering potential therapeutic benefits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous Determination of Dexpanthenol, Lidocaine Hydrochloride, Mepyramine Maleate and their Related Substances by a RP-HPLC Method in Topical Dosage Forms.

Journal of chromatographic science·2018
Same author

Characterization of bevacizumab by dynamic light scattering while maintaining its native structure.

Die Pharmazie·2018
Same author

Development and validation of a LC-FL method for the simultaneous determination of doxorubicin and celecoxib in nanoparticulate fixed dose combination (NanoFDC).

Die Pharmazie·2018
Same author

Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.

Die Pharmazie·2018
Same author

An aquaporin 4 antisense oligonucleotide loaded, brain targeted nanoparticulate system design.

Die Pharmazie·2014
Same author

Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression.

Die Pharmazie·2013

Area of Science:

  • Pharmaceutical Sciences
  • Pharmacokinetics
  • Drug Delivery Systems

Background:

  • Isoniazid (INH) is a cornerstone of tuberculosis preventive therapy, widely used since the 1950s.
  • Variability in INH metabolism (fast vs. slow acetylators) affects therapeutic efficacy.
  • Developing sustained-release formulations aims to achieve consistent therapeutic drug levels.

Purpose of the Study:

  • To design and evaluate sustained-release isoniazid (INH) tablet formulations.
  • To compare the release profiles of INH from different matrix materials.
  • To identify a formulation that provides sustained INH blood concentrations, mimicking slow acetylators.

Main Methods:

  • Investigated INH release from three matrix materials: polymethylmethacrylates, polyvinyl chloride, and carbomer.

Related Experiment Videos

  • Incorporated INH into these matrix systems to create sustained-release tablets.
  • Compared the release rates against conventionally formulated INH tablets.

    • Main Results:

    • The release rate of INH was significantly influenced by the matrix material used.
    • Polymethylmethacrylates and polyvinyl chloride showed varying degrees of sustained release.
    • Tablets formulated with a 30% carbomer matrix exhibited the most effective sustained release of INH.

    Conclusions:

    • Sustained-release isoniazid (INH) formulations can be achieved using specific matrix materials.
    • A 30% carbomer matrix is optimal for developing sustained-release INH tablets.
    • This formulation holds promise for improving tuberculosis chemotherapy by ensuring consistent drug levels.