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High-performance liquid chromatographic determination of tilidine in pharmaceutical dosage forms
D Zivanov-Stakić1, L J Solomun, L J Zivanović
1Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1989
Abstract:
A reversed-phase high performance liquid chromatographic method for the determination of tilidine in bulk drug and its liquid and solid dosage forms is described. The method uses reversed-phase column RP-8 with methanol -0.2% water solution of ammonium carbonate (75:25,v/v) as the mobile phase and UV detector. The time taken for separation is 6.17 min. The response is linear up to 3.6 mmol/l, with recovery levels ranging from 98.2 to 101.2%. The present method is rapid, simple and reproducible.