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Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius
J Paccou1, M H Edwards, K A Ward
1MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Insights
Ischaemic heart disease is linked to lower bone density in the distal radius. This study used high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess bone health in patients with IHD.
Area of Science:
- Orthopedics
- Cardiology
- Radiology
Background:
- High-resolution peripheral quantitative computed tomography (HR-pQCT) offers detailed bone assessment.
- Limited data exist on HR-pQCT findings in patients with ischemic heart disease (IHD).
Purpose of the Study:
- To investigate bone geometry, volumetric bone mineral density (vBMD), and microarchitecture in individuals with IHD.
- To compare bone parameters at the distal radius and tibia between IHD patients and controls.
Main Methods:
- Analysis of data from the Hertfordshire Cohort Study.
- HR-pQCT scans of the distal radius and tibia in 350 participants (aged 71.5-80.5 years).
- Comparison of bone parameters between 75 participants with IHD and 275 without IHD.
Main Results:
- Participants with IHD had lower cortical vBMD (Ct.vBMD) and higher cortical porosity (Ct.Po) at the distal radius.
- No significant differences in trabecular microarchitecture were observed.
- Findings were primarily driven by men; no significant associations were found at the distal tibia.
Conclusions:
- IHD is associated with reduced cortical vBMD at the distal radius.
- HR-pQCT can detect bone changes related to IHD.
Unlabelled:
In this study, high-resolution peripheral quantitative computed tomography (HR-pQCT) was used to investigate geometric, volumetric and microstructural parameters at the distal radius and at the distal tibia in participants with ischaemic heart disease. We found that, compared with participants without ischaemic heart disease, they had substantially lower cortical volumetric bone mineral density (BMD) at the distal radius.
Introduction:
HR-pQCT captures novel aspects of bone geometry and volumetric bone mineral density (vBMD) and offers the ability to measure bone microarchitecture, but data relating measures obtained from this technique in patients with ischemic heart disease (IHD) are lacking.
Methods:
Here, we report an analysis from the Hertfordshire Cohort Study, where we were able to study associations between measures obtained from HR-pQCT of distal radius and distal tibia in 350 participants (184 men and 166 women) aged 71.5-80.5 years with or without IHD (e.g. heart attack, angina or heart failure; n = 75 and n = 275, respectively).
Results:
Analyses for all participants (men and women together) revealed that cortical vBMD (Ct.vBMD) was lower (p < 0.001) and cortical thickness (Ct.th) was not different (p = 0.519), whereas cortical porosity (Ct.Po) was higher (p = 0.016) in participants with IHD at the distal radius. Moreover, trabecular microarchitectural parameters were not significantly different in patients with IHD (p > 0.05 for all). Adjustment for a priori confounders (age, gender, body mass index, smoking status, alcohol consumption, high blood pressure and diabetes mellitus) did not materially affect the relationship described for Ct.vBMD (p = 0.002), but differences in Ct.Po were attenuated. Analyses in men alone revealed that only Ct.vBMD was lower at the distal radius in participants with IHD with and without adjustment for a priori confounders (p = 0.0002 and p = 0.004, respectively), whereas no statistical differences were found in women, although patterns of differences were similar in both sexes. Moreover, no association was found between IHD and bone parameters at the distal tibia either in men or women.
Conclusions:
We have demonstrated that IHD is associated with lower Ct.vBMD of the distal radius.
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