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Updated: Apr 14, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Horizontal-guided Bone Regeneration using a Titanium Mesh and an Equine Bone Graft
Danilo Alessio Di Stefano1, Gian Battista Greco2, Lorenzo Cinci3
1Professor, Department of Dentistry, Vita e Salute San Raffaele University, Milan, Italy, Phone: 390248705703,
Preshaping titanium mesh on a 3D model significantly reduces surgical time for horizontal ridge augmentation. This technique ensures stable, functional implants and promotes new bone formation, making it suitable for routine dental practice.
Area of Science:
- Oral surgery
- Biomaterials science
- Regenerative medicine
Background:
- Guided bone regeneration (GBR) uses barriers like titanium meshes for bone augmentation.
- Titanium meshes offer successful outcomes but require significant intraoperative shaping time.
- Reducing surgical time is crucial for improving GBR procedures.
Observation:
- A stereolithographic model of the patient's jaw was created from CT scans.
- A titanium mesh was preshaped on the stereolithographic model before surgery.
- The preshaped mesh was used for horizontal ridge augmentation in a patient with missing mandibular teeth.
Findings:
- Preshaping the mesh on the model reduced intraoperative time and facilitated faster placement.
- After 24 months, implants were functional, and bone width remained stable.
- Histological analysis confirmed the biocompatibility and remodeling of the bone substitute.
Implications:
- Preshaping titanium mesh on patient-specific models streamlines horizontal ridge augmentation.
- This method enhances surgical efficiency and patient outcomes in GBR.
- The technique is a valuable addition to routine dental implantology practices.
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