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Updated: Apr 14, 2026
Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth
Published on: May 17, 2024
[Expression of helicase DDX41 in human dental pulp tissues and cells]
Xiao-Jun Yang1, Jin Hou, Xin-Zhu Li
1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Objective:
To detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells.
Methods:
The mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry.
Results:
Strong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts.
Conclusion:
DDX41/STING-dependent TBK1-IRF3-IFN-β signaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.
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