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Updated: Apr 14, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle
Ryan P McNabb1, Pratap Challa2, Anthony N Kuo2
1Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710 USA ; Department of Biomedical Engineering, Duke University, Durham, NC 27708 USA.
Abstract:
Clinically, gonioscopy is used to provide en face views of the ocular angle. The angle has been imaged with optical coherence tomography (OCT) through the corneoscleral limbus but is currently unable to image the angle from within the ocular anterior chamber. We developed a novel gonioscopic OCT system that images the angle circumferentially from inside the eye through a custom, radially symmetric, gonioscopic contact lens. We present, to our knowledge, the first 360° circumferential volumes (two normal subjects, two subjects with pathology) of peripheral iris and iridocorneal angle structures obtained via an internal approach not typically available in the clinic.
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