Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aptamers: Current Applications in Leukemia Diagnostics and Therapeutics.

Nucleic acid therapeutics·2026
Same author

Translational opportunities in aptamer and nanobody lateral flow assays within the WHO REASSURED framework.

Sensors & diagnostics·2026
Same author

Organic electrolyte gated field effect transistor for detecting alpha synuclein longitudinally in Parkinsonism mouse model.

Npj biosensing·2025
Same author

Simple solution and paper-based fluorescent aptasensors for toxic metal ions, thallium(l) and lead(ll).

Analytical and bioanalytical chemistry·2024
Same author

Selection of DNA aptamers that prevent the fibrillization of α-synuclein protein in cellular and mouse models.

Molecular therapy. Nucleic acids·2024
Same author

Iodinated organic molecule as tag for inductively coupled Plasma-mass spectrometry aptamer assays.

Talanta·2023

Related Experiment Video

Updated: Feb 20, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

7.2K

Outlook for aptamers after twenty five years.

Phepafatso K Tsae, Maria C DeRosa1

  • 1Department of Chemistry, Faculty of Science, Carleton University, 1125 Colonel By Drive, Ottawa, Canada. maria.derosa@carleton.ca.

Current Topics in Medicinal Chemistry
|April 26, 2015
PubMed
Summary

Aptamers, powerful synthetic receptors, are revolutionizing therapeutics, imaging, and diagnostics. This review highlights their advantages over antibodies and explores future applications of this technology.

More Related Videos

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K
Primer-Free Aptamer Selection Using A Random DNA Library
11:14

Primer-Free Aptamer Selection Using A Random DNA Library

Published on: July 26, 2010

25.5K

Related Experiment Videos

Last Updated: Feb 20, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

7.2K
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K
Primer-Free Aptamer Selection Using A Random DNA Library
11:14

Primer-Free Aptamer Selection Using A Random DNA Library

Published on: July 26, 2010

25.5K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Aptamers are powerful synthetic molecular recognition elements that emerged 25 years ago.
  • Aptamers have been compared to antibodies since their inception.
  • Aptamers are increasingly finding applications in various fields.

Purpose of the Study:

  • To review the applications of aptamers.
  • To highlight the advantages of aptamers over antibodies in specific applications.
  • To discuss future applications of aptamer technology.

Main Methods:

  • Literature review of aptamer applications.
  • Comparative analysis of aptamers and antibodies.
  • Identification of key advantages of aptamers.

Main Results:

  • Aptamers offer significant advantages over antibodies in therapeutics, imaging, diagnostics, and biosensors.
  • Successful aptamer applications have leveraged these inherent advantages.
  • The review identifies promising and successful aptamer-based applications.

Conclusions:

  • Aptamers are a versatile and enabling technology with a growing impact.
  • Exploiting aptamer advantages over antibodies is key to successful applications.
  • Future research and development hold significant promise for aptamer technology.