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Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
Published on: October 31, 2007
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Treating posttransplantation diabetes mellitus
María José Pérez-Sáez1, Mónica Marín-Casino, Julio Pascual
1Hospital del Mar, Nephrology Department , Passeig Maritim 25-29, Barcelona , Spain +34932483162 ; +34932483373 ; julpascual@gmail.com.
Expert Opinion on Pharmacotherapy
|April 26, 2015
Summary
Post-transplant diabetes mellitus (PTDM) is a significant cardiovascular risk in kidney transplant recipients. More research is needed for effective PTDM prevention and management strategies to improve patient survival.
Area of Science:
- Nephrology
- Transplantation
- Endocrinology
Background:
- Long-term survival in kidney transplant recipients is challenged by cardiovascular risk.
- Post-transplant diabetes mellitus (PTDM) is a major contributor to this cardiovascular risk.
Purpose of the Study:
- To review the prevalence, risk factors, prevention, and treatment of PTDM.
- To identify gaps in current research and suggest future directions for PTDM management.
Main Methods:
- Literature search using PubMed.
- Focused on prevalence, risk factors, prevention, and treatment of PTDM.
Main Results:
- High-quality clinical trials on PTDM prevention and management are lacking.
- Molecular and mechanistic studies in PTDM are infrequent.
- Current surrogate endpoints for PTDM are extrapolated from the general population.
Conclusions:
- High-quality clinical trials and basic/translational studies are crucial for PTDM research.
- Developing effective strategies for PTDM prevention and management, including tailored immunosuppression and early antidiabetic treatment, is essential.
- Further evidence is needed to establish the safety and efficacy of newer oral hypoglycemic agents for PTDM treatment.
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