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Ultrasonography

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...

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Does adding diffuse optical tomography to sonography improve differentiation between benign and malignant breast

Bo La Yun¹, Sun Mi Kim², Mijung Jang¹

¹Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea (B.L.Y., S.M.K., M.J.); Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (H.S.A.); Total Healthcare Center, Kangbuk Samsung Hospital, Seoul, Korea (C.Y.L.); CHA Gangnam Health Promotion Center, Seoul, Korea (M.S.K.); Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, Korea (S.A.K.); Department of Electronic Engineering and Sogang Institute of Advanced Technology, Sogang University, Seoul, Korea (T.-K.S., Y.Y., J.H.C.); and Department of Radiology, Sungkyunkwan University Samsung Changwon Hospital, Changwon, Korea (Y.K.).

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine

|April 26, 2015

Summary

Adding diffuse optical tomography to breast ultrasounds significantly improves accuracy in distinguishing benign from malignant lesions, reducing unnecessary biopsies.

Keywords:

breast neoplasms breast ultrasound diagnosis differential diagnosis optical tomography receiver operating characteristic curve sonography

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Area of Science:

Medical Imaging
Radiology
Biomedical Engineering

Background:

Differentiating benign from malignant breast lesions is crucial for effective patient management.
Conventional sonography (ultrasound) is a primary tool, but its accuracy can be limited.

Purpose of the Study:

To evaluate the added diagnostic value of diffuse optical tomographic (DOT) categories when combined with conventional sonography for breast lesion characterization.
To assess the impact of DOT on diagnostic accuracy and interobserver agreement.

Main Methods:

A retrospective review of 145 breast lesions (116 benign, 29 malignant) from 145 women.
Five radiologists independently assessed sonograms with and without DOT categories, scoring malignancy suspicion and assigning Breast Imaging Reporting and Data System (BI-RADS) classifications.
Diagnostic performance was analyzed using receiver operating characteristic (ROC) curves, and reader agreement was assessed via intraclass correlation coefficients.

Main Results:

Combining DOT with sonography significantly improved diagnostic accuracy, with the area under the ROC curve increasing from 0.923 to 0.969 (P = .039).
Interobserver agreement improved substantially, from an intraclass correlation coefficient of 0.798 for sonography alone to 0.904 with DOT.
Specificity increased significantly with DOT, particularly when strictly applied (from 19.5% to 68.3%), without compromising sensitivity.

Conclusions:

The integration of diffuse optical tomographic categories into sonographic evaluations enhances diagnostic performance for breast lesions.
This combined approach has the potential to significantly reduce false-positive biopsy recommendations, improving clinical decision-making.