Related Experiment Video

Updated: Feb 18, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

27.8K

Sulbactam/ampicillin in the treatment of pediatric infections

G Kanra1, G Secmeer, E Akalin

  • 1Department of Infectious Diseases, Medical School of Hacettepe University, Ankara, Turkey.

Diagnostic Microbiology and Infectious Disease
|July 1, 1989
PubMed

Insights

Sulbactam/ampicillin demonstrated high efficacy and safety in treating pediatric infections, achieving a 98.7% cure rate across various conditions. This antibiotic combination proved effective for skeletal, thoracic, and soft tissue infections in children.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Antimicrobial Therapy

Background:

  • Pediatric infections require effective and safe antimicrobial agents.
  • Sulbactam/ampicillin is a combination antibiotic with a broad spectrum of activity.
  • Evaluating its use in diverse pediatric patient populations is crucial.

Purpose of the Study:

  • To assess the safety and efficacy of sulbactam/ampicillin in treating various infections in pediatric patients.
  • To determine the overall cure rate and identify any adverse events associated with the treatment.

Main Methods:

  • A cohort of 78 pediatric patients (34 days to 17 years) received intravenous or intramuscular sulbactam/ampicillin.
  • Treatment was administered 3-4 times daily for skeletal, systemic salmonellosis, intrathoracic, and soft tissue infections.
  • Dosage was typically 200 mg ampicillin/100 mg sulbactam per kg/day for 8-23 days.

Main Results:

  • An overall cure rate of 98.7% was achieved in 78 study patients.
  • A single case of Escherichia coli resistant to sulbactam/ampicillin was noted in an abscess.
  • Only one patient experienced a mild rash, not requiring treatment cessation.

Conclusions:

  • Sulbactam/ampicillin is a safe and highly effective therapeutic option for a range of pediatric infections.
  • The combination antibiotic is well-tolerated, with minimal adverse effects observed.
  • Further research may explore its utility against resistant strains.

More Related Videos

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

15.3K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
324
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
341
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
257
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
284
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
474
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
7.0K