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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

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Conformational isomerism in solid state of AMG 853--structure studies using solid-state nuclear magnetic resonance

Y-H Kiang1, Karthik Nagapudi1, Tian Wu1

  • 1Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320.

Journal of Pharmaceutical Sciences
|April 28, 2015
PubMed
Summary

Two coexisting conformational isomers of AMG 853, a dual DP and CRTH2 antagonist, were identified in the crystal lattice. Solid-state NMR and X-ray diffraction confirmed their presence and disorder in the fluorine atom's crystal structure.

Keywords:
X-ray powder diffractometrycrystal structuresolid statesolid state NMR

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