Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules
Kazunobu Toshima1, Daisuke Takahashi2
1Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan. toshima@applc.keio.ac.jp.
Abstract:
Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.
