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Updated: Aug 10, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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Complex segregation analysis for a three-allele locus: experience from an analysis of acid phosphatase activity
L Iselius1, D A Evans, L C Eze
1Department of Community Medicine, Southampton General Hospital, England.
Abstract:
A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.
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