Antimicrobial metabolites from endophytic Streptomyces sp. YIM61470

Six compounds were isolated from Streptomyces sp. YIM61470, and their structures elucidated by spectral analysis as (R)-1-O-(phenylacetyl)glycerol (1), 4',5-dihydroxy-6-(3,3-dimethylallyl)-7-methoxyflavanone (2), (32R,33R,34S) -32,33,34,35-bacteriohopanetetrol (3), MKN-003C (4), cyclo (L-Pro-L-Gly) (5), and cyclo(L-Pro-L-Tyr) (6). Compound 1, an chiral monoacylglycerol, was isolated from a natural source for the first time. Compound 2 was first found in microorganisms, and compound 3, a bacteriohopanoid, was found first in the genus Streptomyces. Compounds 1-6 showed weak anti-microbial activity.