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[Control study on antimicrobial resistance of invasive and non-invasive Streptococcus pneumoniae in children]

Li-Hong Dai1, Lin Dong, Hai-Yan Li

  • 1Department of Respiratory Medicine, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. donglin@wzhealth.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 29, 2015
PubMed

Insights

Antimicrobial resistance in invasive Streptococcus pneumoniae (SP) strains in children is high, with significant resistance to common antibiotics. This study highlights the need for careful antimicrobial drug selection for treating SP infections.

Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Antimicrobial Resistance

Context:

  • Streptococcus pneumoniae (SP) is a leading cause of invasive pneumococcal diseases (IPD) and lower respiratory tract infections in children.
  • Understanding antimicrobial resistance patterns is crucial for effective treatment and public health strategies.

Purpose:

  • To investigate the antimicrobial resistance profiles of invasive and non-invasive SP strains in pediatric populations.
  • To guide the appropriate use of antimicrobial agents in managing SP infections.

Summary:

  • A study of 70 children with IPD and 164 with SP-caused lower respiratory tract infections identified 82 invasive SP strains.
  • Invasive SP detection rates declined from 2009-2013. Penicillin-nonsusceptible SP was found in 27% of invasive and 17% of non-invasive strains.
  • Multidrug resistance rates were high (89% invasive, 93% non-invasive), with significant resistance to cephalosporins and carbapenems among penicillin-nonsusceptible strains.

Impact:

  • Findings demonstrate a decreasing trend in invasive SP detection but persistent high rates of antimicrobial resistance.
  • Drug susceptibility data provides critical guidance for optimizing antimicrobial therapy in pediatric pneumococcal infections.
  • This research underscores the importance of ongoing surveillance and tailored treatment approaches for SP.
Abstract

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