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HLA associations with obesity.

R R Fabsitz1, J M Nam, J Gart

  • 1National Heart, Lung and Blood Institute, Bethesda, Md.

Human Heredity
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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Human leukocyte antigen (HLA) Aw30 allele is linked to a 2.61 increased risk of obesity. This genetic association was observed in both males and females within the Framingham Heart Study cohort.

Area of Science:

  • Genetics
  • Immunology
  • Epidemiology

Background:

  • Obesity is a complex health issue with potential genetic underpinnings.
  • Human Leukocyte Antigen (HLA) genes are known to influence immune responses and have been investigated for associations with various diseases.

Purpose of the Study:

  • To investigate the association between specific Human Leukocyte Antigen (HLA) alleles and obesity in a subgroup of the Framingham Heart Study participants.
  • To identify potential genetic markers for obesity risk.

Main Methods:

  • Analysis of HLA typing data from 351 Framingham Heart Study subjects (143 males, 208 females).
  • Obesity classification based on maximum Body Mass Index (BMI) exceeding the 95th percentile from NHANES II criteria.
  • Comparison of HLA allele frequencies between obese and non-obese groups, stratified by sex.

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  • Statistical adjustment for potential confounding variables to determine relative risk.

    • Main Results:

    • The HLA Aw30 allele was found to be significantly more frequent in obese subjects (both males and females).
    • While HLA Bw35 showed a trend in obese females, it was not statistically significant after adjustments.
    • The relative risk for obesity associated with the HLA Aw30 allele remained significant at 2.61 after adjusting for confounding factors.

    Conclusions:

    • The HLA Aw30 allele is significantly associated with an increased risk of obesity.
    • HLA genetics may play a role in the susceptibility to obesity, warranting further investigation.