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Serum copeptin levels in predicting nondippers in newly diagnosed hypertension
Fatih Uzun1, Ismail Biyik, Ibrahim F Akturk
1Departments of aCardiology bMicrobiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul cDepartment of Cardiology, Usak State Hospital Heart Center, Usak dDepartment of Cardiology, Ordu State Hospital, Ordu, Turkey.
Insights
High copeptin levels may predict the nondipper blood pressure pattern in new hypertension cases. This pattern is linked to poorer cardiovascular outcomes, making copeptin a potential early indicator.
Area of Science:
- Cardiology
- Endocrinology
- Hypertension Research
Background:
- The nondipper hypertension pattern is linked to adverse cardiovascular events.
- Identifying predictors for the nondipper pattern is crucial for risk stratification.
Purpose of the Study:
- To investigate if high copeptin levels can predict the nondipper pattern in newly diagnosed hypertensive patients.
- To explore the association between serum copeptin levels and the nondipper blood pressure phenotype.
Main Methods:
- Seventy-six newly diagnosed hypertensive patients were enrolled.
- Ambulatory blood pressure monitoring was used to classify patients as dippers or nondippers.
- Serum copeptin levels were measured and compared between the two groups.
Main Results:
- Mean serum copeptin levels were significantly higher in the nondipper group compared to the dipper group (P=0.026).
- Significant positive correlations were observed between serum copeptin levels and nocturnal systolic (r=0.593) and diastolic blood pressure (r=0.523).
Conclusions:
- Elevated serum copeptin levels are predictive of the nondipper pattern in individuals with newly diagnosed hypertension.
- Copeptin may serve as a valuable biomarker for identifying hypertensive patients at higher cardiovascular risk due to the nondipper pattern.
Objectives:
The nondipper pattern in hypertension is associated with worse cardiovascular outcomes. In this study, we hypothesized that high copeptin levels could predict nondippers among hypertensive patients and investigated the associations between copeptin levels and nondipper pattern in newly diagnosed hypertensive patients.
Methods:
Ambulatory blood pressure measurements were obtained and the patients were divided into two groups according to ambulatory blood pressure measurement as nondippers and dippers. Serum copeptin levels were measured in addition to routine laboratory investigations. A total of 76 patients were included in the study.
Results:
The clinical and laboratory characteristics of the two groups were similar. The mean copeptin values were found to be significantly higher in the nondipper hypertensive group [1.66 (1.19-4.01) and 1.35 (1.12-2.09) IU/ml, respectively, P=0.026]. In the correlation analysis, no correlation was found between copeptin levels and daytime diastolic blood pressure, but there were weak positive correlations with daytime systolic, 24 h systolic, and diastolic blood pressure values (r=0.335, P=0.034, r=0.350, P=0.027, r=0.372, P=0.018, respectively). However, there were significant positive correlations between serum copeptin levels and nocturnal systolic and diastolic blood pressure values (r=0.593, P<0.001, r=0.523, P=0.001, respectively).
Conclusion:
This study showed that high serum copeptin levels could predict the nondipper pattern in newly diagnosed hypertension.
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