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2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.
Michael J Flister1, Jeremy W Prokop, Jozef Lazar
1Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, 53226, WI, USA, mflister@mcw.edu.
Journal of Cardiovascular Translational Research
|April 30, 2015
Summary
Rats are crucial for cardiovascular disease (CVD) research. New genetic modification tools now enable the development of advanced rat models to study CVD molecular mechanisms, improving clinical translation.
Area of Science:
- Cardiovascular Science
- Genetics
- Animal Models
Background:
- Rats are established physiological models for cardiovascular disease (CVD) research.
- Inbred rat strains are selected for CVD susceptibility or resistance, offering a relevant background for human disease studies.
- Genetically modified rat models are essential for investigating molecular mechanisms in clinically translatable settings.
Framework:
- Development of genetically modified rat models for CVD research.
- Utilizing existing CVD-selected rat strains.
- Leveraging recent advancements in genome modification technologies.
Implementation:
- High-level description of strategies for genetic modification in rats.
- Focus on creating models to test molecular mechanisms of CVD.
- Application in preclinical research for cardiovascular diseases.
Implications:
- Enhanced understanding of cardiovascular disease (CVD) pathogenesis.
- Improved preclinical testing of therapeutic candidates.
- Advancement of clinically translatable cardiovascular research using genetically engineered rats.
