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Updated: Apr 13, 2026
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Do human tumor-associated viruses play a role in the development of synovial sarcoma?
Ulrich Lenze1, Florian Pohlig1, Heinrich Mühlhofer1
1Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Background:
To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas.
Findings:
In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected.
Conclusion:
An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.
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