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Updated: Apr 13, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
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Temperature management after cardiac arrest.

Niklas Nielsen1, Hans Friberg

  • 1Department of Clinical Sciences, Section of Anesthesiology and Intensive Care, Lund University, Lund, Sweden.

Current Opinion in Critical Care
|April 30, 2015
PubMed
Summary
This summary is machine-generated.

Prehospital hypothermia with cold saline does not improve outcomes for cardiac arrest survivors. Targeted temperature management at 33°C or 36°C in intensive care units yields similar survival and neurological function results.

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Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Neurology

Background:

  • Therapeutic hypothermia is a key component of post-cardiac arrest care.
  • Recent large-scale trials have re-evaluated its efficacy and optimal protocols.

Purpose of the Study:

  • To review recent findings on temperature management after cardiac arrest.
  • To discuss implications for future clinical trials and practice.

Main Methods:

  • Analysis of two major trials: one on prehospital hypothermia induction with cold saline, and another comparing targeted temperature management at 33°C vs. 36°C in ICUs.
  • Inclusion of 1364 patients in the prehospital trial and 950 unconscious patients in the ICU trial.

Main Results:

  • Prehospital hypothermia with cold saline did not improve survival or neurological function and suggested potential harm.
  • No significant difference in survival or neurological outcomes was observed between targeted temperature management at 33°C and 36°C in intensive care units.

Conclusions:

  • Inducing hypothermia prehospital with cold crystalloid infusion offers no benefit to cardiac arrest patients.
  • Targeting 36°C in intensive care units is as effective as targeting 33°C for post-cardiac arrest care.