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Updated: Apr 13, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Hyperuricemia is an independent predictive factor for left ventricular diastolic dysfunction in patients with chronic
Leszek Gromadziński1, Beata Januszko-Giergielewicz2, Piotr Pruszczyk3
1Department of Internal Diseases, Gastroenterology and Hepatology, University Clinical Hospital in Olsztyn, Poland.
Insights
High uric acid (UA) levels are linked to left ventricular (LV) diastolic dysfunction (DD) in chronic kidney disease (CKD) patients. Hyperuricemia independently predicts LV diastolic dysfunction in this population.
Area of Science:
- Nephrology
- Cardiology
- Clinical Biochemistry
Background:
- Elevated serum uric acid (UA) is a known poor prognostic factor in chronic heart failure and chronic kidney disease (CKD).
- The relationship between hyperuricemia and left ventricular (LV) diastolic dysfunction (DD) in CKD patients requires further investigation.
Purpose of the Study:
- To assess the impact of hyperuricemia on LV diastolic dysfunction (DD) in patients with chronic kidney disease (CKD).
Main Methods:
- The study included 50 patients with CKD (stages 2-5).
- Standard echocardiography and tissue Doppler imaging (TDI) were used to assess LV diastolic function (EmLV).
- Serum UA and NT-proBNP levels were measured; patients were grouped based on EmLV values (<8 cm/s for DD, ≥8 cm/s for normal function).
Main Results:
- Patients with LV diastolic dysfunction (DD+) had significantly higher serum UA levels compared to those with normal diastolic function (DD-) [6.7 vs 5.8 mg/dL].
- Serum UA levels demonstrated good diagnostic performance for LV diastolic dysfunction (ROC AUC = 0.734, p=0.001), with a UA value > 6.0 mg/dL showing 76.9% sensitivity and 62.5% specificity.
- Elevated UA level (> 6.0 mg/dL) was an independent predictor of LV diastolic dysfunction (OR = 14.3, p=0.006).
Conclusions:
- Hyperuricemia is an independent predictive factor for left ventricular diastolic dysfunction in patients with chronic kidney disease.
- Monitoring and managing uric acid levels may be crucial for preventing or treating diastolic dysfunction in CKD patients.
Background:
It has been reported that elevated serum uric acid (UA) levels is an independent factor of poor prognosis in patients with chronic heart failure and chronic kidney disease (CKD).
Objectives:
In our study, we assessed the potential impact of hyperuricemia on left ventricular (LV) diastolic dysfunction (DD) in patient with CKD.
Material And Methods:
The study group consisted of 50 patients with CKD, stages 2-5. Standard echocardiography and tissue Doppler imaging (TDI) were performed. The levels of UA and N-terminal prohormone brain natriuretic peptide (NT-proBNP) were determined. Patients were divided into two groups according to the results of peak mitral annular early diastolic velocity (EmLV): group with LV diastolic dysfunction (EmLV < 8 cm/s) DD (+) and group with normal LV diastolic function DD (-), when EmLV ≥ 8 cm/s.
Results:
Patients DD (+) group, as compared to DD (-) patients were characterized by significantly higher serum UA levels [6.7 (4.4-14.3) mg/dL vs 5.8 (1.9-8.9) mg/dL, p = 0.004] respectively. The area under the receiver operating characteristic (ROC) curve was of serum UA levels for the detection of LV diastolic dysfunction was 0.734, 95% confidence interval (CI) 0.590-0.849, p = 0.001, whereas ROC derived UA value of > 6.0 mg/dL was characterized by a sensitivity of 76.9% and specificity of 62.5% for diagnosing LV diastolic dysfunction. The independent variable predicting LV diastolic dysfunction as measured by a multivariate logistic regression analysis was UA level > 6.0 mg/dL with odds ratio (OR) = 14.3 (95% CI 2.0-103.2), p = 0.006.
Conclusions:
Hyperuricemia is an independent predictive factor for LV diastolic dysfunction in patients with CKD.
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