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Reference values for reticulocyte parameters and hypochromic RBC in healthy children.

C Teixeira1, J Barbot2, M I Freitas1

  • 1Department of Pathology, Laboratory Hematology Unit, Centro Hospitalar do Porto, Porto, Portugal.

International Journal of Laboratory Hematology
|April 30, 2015
PubMed
Summary
This summary is machine-generated.

This study establishes pediatric reference values for novel reticulocyte and hypochromic red blood cell parameters using the ADVIA 2120 analyzer. These findings provide crucial data for pediatric hematology diagnostics and research.

Keywords:
Reticulocyte parametershematology analyzerhypochromic red blood cellspediatricsreference values

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Area of Science:

  • Hematology
  • Pediatrics
  • Clinical Diagnostics

Background:

  • Modern hematology analyzers offer new erythrocyte and reticulocyte parameters valuable in pediatric care.
  • Pediatric reference ranges for these indices are currently limited.
  • This study addresses the need for method-specific pediatric reference values.

Purpose of the Study:

  • To establish pediatric reference values for reticulocyte parameters and hypochromic red blood cells.
  • To utilize the ADVIA 2120 hematology analyzer for these measurements.
  • To provide data for improved clinical practice and research in pediatrics.

Main Methods:

  • Prospective study involving 311 healthy children aged 6 months to 18 years.
  • Hematological parameters measured using the ADVIA 2120 analyzer.
  • Participants grouped into three age cohorts; gender distribution analyzed for ages ≥12 years.

Main Results:

  • Provided age- and gender-specific reference limits for reticulocyte hemoglobin content (CHr or Ret-He), Delta-He, immature reticulocyte fraction (IRF), and percentage of hypochromic red blood cells (%Hypo).
  • Significant gender differences observed for Delta-He, IRF, and %Hypo in the 12-17 years group.
  • CHr showed no significant gender variation across all age groups (median 30.8 ± 1.7 pg).

Conclusions:

  • Establishing reliable pediatric reference intervals for novel hematological parameters is essential.
  • These reference values offer valuable prospects for clinical practice in pediatrics.
  • The findings support the use of these parameters in pediatric research.