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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Correlation of diffusion tensor imaging parameters in the canine brain.

Dalun Leong¹, Evan Calabrese², Leonard E White³

¹Duke-NUS School of Medicine; Singapore.

The Neuroradiology Journal

|April 30, 2015

Summary

Radial diffusivity (RD) and apparent diffusion coefficient (ADC) in white matter correlate strongly, suggesting they reflect myelination. Fractional anisotropy (FA) also correlates with RD and ADC but reflects additional microstructural features.

Keywords:

canine brain diffusion tensor imaging

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Last Updated: Apr 13, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Area of Science:

Neuroimaging
Biophysics

Background:

Diffusion Tensor Imaging (DTI) provides insights into white matter microstructure.
Key DTI parameters include fractional anisotropy (FA), radial diffusivity (RD), and apparent diffusion coefficient (ADC).
Understanding the interrelationships between these parameters is crucial for accurate interpretation of white matter integrity.

Purpose of the Study:

To investigate the correlation between ex vivo DTI parameters (FA, RD, ADC) in canine white matter.
To test the hypothesis that RD and ADC correlate more closely with each other than with FA.

Main Methods:

Post mortem DTI imaging of three canine brains using a 7T MR scanner.
Generation of FA, RD, and ADC maps.
Linear regression analysis of DTI parameters within 14 white matter regions of interest.

Main Results:

RD showed significant correlations with both FA (R² = 0.3053) and ADC (R² = 0.6755).
The correlation between RD and ADC was substantially stronger than between RD and FA.
ADC did not show a significant correlation with FA (R² = 0.101).

Conclusions:

RD and ADC likely reflect similar microstructural features, primarily myelination.
FA appears to be influenced by myelination as well as other microstructural characteristics that restrict water diffusion.
These findings aid in the nuanced interpretation of DTI metrics for white matter analysis.