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Related Experiment Video

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Transcutaneous spinal direct current stimulation modulates human corticospinal system excitability.

Tommaso Bocci1, Sara Marceglia2, Maurizio Vergari3

  • 1Fondazione IRCCS "Ca' Granda" Ospedale Maggiore di Milano, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milan, Italy; Unità Operativa di Neurologia, Dipartimento di Neuroscienze, Università di Pisa, Pisa, Italy;

Journal of Neurophysiology
|May 1, 2015
PubMed
Summary

Thoracic direct current stimulation (tsDCS) differently impacts lower limb corticospinal excitability based on polarity. Anodal tsDCS increased motor threshold, while cathodal tsDCS increased motor evoked potential area in leg muscles.

Keywords:
corticospinal systemdirect current stimulationmotor potentialsspinal cordspinal cord stimulationtranscranial direct current stimulationtranscranial magnetic stimulationtranscutaneous spinal direct current stimulation

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Area of Science:

  • Neuroscience
  • Motor Control
  • Neuromodulation

Background:

  • Transcutaneous spinal direct current stimulation (tsDCS) is explored for modulating neural pathways.
  • Previous research on thoracic tsDCS focused on spinal reflexes, not corticospinal excitability in limbs.
  • Understanding tsDCS effects on upper and lower limb motor control is crucial for therapeutic applications.

Purpose of the Study:

  • To investigate the effects of anodal and cathodal thoracic tsDCS on corticospinal excitability in upper and lower limbs.
  • To determine if tsDCS influences motor evoked potentials (MEPs), H-reflex, and F-waves in healthy individuals.

Main Methods:

  • 14 healthy subjects received thoracic tsDCS (2.5 mA, 20 min) at T9-T11.
  • Motor evoked potentials (MEPs) and F-waves were recorded from hand (ADM) and foot (AH) muscles.
  • Soleus H-reflex was assessed in 8 subjects; all measures taken pre- and post-stimulation (0 and 30 min).

Main Results:

  • Neither anodal nor cathodal tsDCS altered upper limb MEPs or F-waves.
  • Anodal tsDCS increased lower limb motor resting threshold but did not affect MEP area or latency.
  • Cathodal tsDCS increased lower limb MEP area without altering resting motor threshold or latency; H-reflex remained unchanged.

Conclusions:

  • Thoracic tsDCS induces polarity-specific, lasting changes (>30 min) in corticospinal excitability.
  • These effects selectively target lower limb motor responses innervated by lumbar and sacral spinal neurons.
  • tsDCS offers a potential tool for modulating lower limb motor pathways.