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Updated: Apr 13, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

NGL Viewer: a web application for molecular visualization.

Alexander S Rose¹, Peter W Hildebrand²

¹Institut für Medizinische Physik und Biophysik, AG ProteInformatics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany alexander.rose@charite.de.

Nucleic Acids Research

|May 1, 2015

Summary

This summary is machine-generated.

The NGL Viewer is a web application for visualizing macromolecular structures. It uses modern web technologies for interactive display of large molecular complexes, supporting various file formats and representations.

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Published on: July 16, 2017

Area of Science:

Structural Biology
Bioinformatics
Computational Chemistry

Background:

Macromolecular structure visualization is crucial for understanding biological processes.
Traditional visualization tools often rely on outdated plugins (e.g., Flash, Java Applets) that are being phased out.
There is a need for modern, web-based solutions for accessing and analyzing structural data.

Purpose of the Study:

To introduce the NGL Viewer, a novel web application for interactive macromolecular structure visualization.
To leverage modern web browser capabilities (e.g., WebGL) for enhanced molecular graphics.
To provide life scientists with an accessible and versatile tool for exploring structural data.

Main Methods:

Development of a web application utilizing WebGL for hardware-accelerated molecular graphics.
Implementation of a graphical user interface for intuitive navigation and manipulation of molecular structures.
Support for common structural file formats (e.g., PDB, mmCIF) and diverse molecular representations (e.g., cartoon, spacefill, licorice).

Main Results:

The NGL Viewer enables interactive visualization of large molecular complexes directly in web browsers.
The application is independent of third-party plugins, ensuring long-term usability.
It offers a user-friendly interface for accessing and analyzing structural data, supporting various visualization styles.

Conclusions:

The NGL Viewer provides a powerful, accessible, and future-proof platform for macromolecular structure visualization.
Its embeddable nature allows for specialized visualizations within databases and computational results.
This tool empowers life scientists to better utilize and interpret structural biology data.