Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Organization of the Brain01:30

Organization of the Brain

3.9K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.9K
Brain Imaging01:14

Brain Imaging

996
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
996

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arousal modulates functional connectivity through structured and hemispherically asymmetric community architecture during wakefulness.

eLife·2026
Same author

Dissociation between physical reasoning and tool use in individuals with left hemisphere brain damage.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same author

Spatiotemporal dynamics of the human cortical functional hierarchy across the lifespan.

Nature communications·2026
Same author

Cortical functional hierarchy disruption following subcortical stroke.

BMC medicine·2026
Same author

Combining transcranial direct current stimulation and computerized cognitive training for post-stroke cognitive recovery: Study protocol for a randomized controlled trial with optimized temporal intervention sequences.

PloS one·2026
Same author

Evaluation of a pharmacist-led patient-self-testing model for warfarin management in patients undergoing mechanical heart valve replacement in China: a multicentre, open-label, randomised, controlled trial.

BMJ open·2026

Related Experiment Video

Updated: Apr 13, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.2K

The white matter structural network underlying human tool use and tool understanding.

Yanchao Bi1, Zaizhu Han2, Suyu Zhong1

  • 1State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 1, 2015
PubMed
Summary
This summary is machine-generated.

Specific white matter tracts in the left hemisphere are crucial for tool use and conceptual understanding. Damage to these tracts, identified using diffusion imaging, correlates with deficits in tool processing abilities.

Keywords:
brain-damaged patientdiffusion tensor imagingstructural networktool concepttool usevoxel-based lesion-symptom mapping

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.7K
Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.9K

Related Experiment Videos

Last Updated: Apr 13, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.2K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.7K
Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.9K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroanatomy

Background:

  • Tool use is a defining human trait supported by widespread brain networks.
  • The specific white matter (WM) connections underlying tool use and conceptualization remain largely unknown.

Purpose of the Study:

  • To identify the WM tracts essential for tool use and tool concept processing.
  • To investigate the relationship between WM tract integrity and deficits in tool-related behaviors.

Main Methods:

  • Deterministic fiber tracking in healthy individuals to map WM connections between 14 tool-processing cortical regions.
  • Assessing WM tract integrity in 86 brain-damaged patients using lesion percentage and fractional anisotropy (FA) values.
  • Evaluating behavioral deficits in tool use and conceptual tasks.

Main Results:

  • Three left hemisphere tracts, overlapping with the superior longitudinal fasciculus, are critical for tool use; damage correlates with deficits.
  • These tracts, plus five additional left hemisphere tracts (including SLF, IFOF, UF, ATR), are vital for tool concept processing.
  • Voxel-based symptom mapping confirmed these findings.

Conclusions:

  • Specific WM structural networks, primarily in the left hemisphere, underpin tool use and conceptual understanding.
  • This study elucidates the anatomical basis of the human tool knowledge network.