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Related Experiment Video

Updated: Apr 13, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
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Physiological and pathophysiological roles for phospholipase D.

Rochelle K Nelson1, Michael A Frohman2

  • 1Graduate Program in Physiology and Biophysics Stony Brook University, Stony Brook, NY.

Journal of Lipid Research
|May 1, 2015
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Summary
This summary is machine-generated.

Mammalian phospholipase D (PLD) enzymes have diverse roles, from signaling lipid generation to RNA processing and membrane trafficking. Emerging research links PLD family members to various diseases, presenting therapeutic targets.

Keywords:
cancerlipid signalingphosphatidic acid

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • The phospholipase D (PLD) superfamily encompasses enzymes with critical cellular functions.
  • PLD enzymes hydrolyze phosphatidylcholine to generate the second messenger phosphatidic acid.
  • Beyond enzymatic activity, PLDs are implicated in RNA processing and membrane trafficking.

Purpose of the Study:

  • To review the multifaceted roles of mammalian PLD enzymes.
  • To highlight the involvement of PLD family members in various disease pathologies.
  • To discuss the therapeutic potential of targeting PLD in disease.

Main Methods:

  • Review of recent advances in genome-wide association studies.
  • Analysis of RNA interference screening data.
  • Integration of next-generation sequencing findings.
  • Examination of phenotypic analyses from knockout mouse models.

Main Results:

  • PLD family members play roles in autoimmune diseases.
  • PLD involvement is noted in infectious and neurodegenerative diseases.
  • PLD dysregulation is linked to cardiovascular disease and cancer.
  • Small molecule inhibitors targeting PLD are under development for disease treatment.

Conclusions:

  • Mammalian PLD enzymes exhibit diverse enzymatic and non-enzymatic functions.
  • PLD family members are increasingly recognized as key players in numerous human diseases.
  • Targeting PLD with small molecule inhibitors represents a promising therapeutic strategy.