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Challenges of biomolecular detection at the nanoscale: nanopores and microelectrodes
Klaus Mathwig1, Tim Albrecht2, Edgar D Goluch3
1†Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands.
Analytical Chemistry
|May 1, 2015
Abstract:
The interest in analytical devices, which typically rely on the reactivity of a biological component for specificity, is growing rapidly. In this Perspective, we highlight current challenges in all-electrical biosensing as these systems shrink toward the nanoscale and enable the detection of analytes at the single-molecule level. We focus on two sensing principles: nanopores and amperometric microelectrode devices.
