Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

349
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
349
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

404
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
404
Obesity01:24

Obesity

1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

306
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
306
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.7K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.7K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

603
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
603

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nordic Multimorbidity Index, Charlson, Elixhauser and count-based comorbidity indices for mortality risk: a comparative nationwide cohort study using national health registers in Sweden.

BMJ open·2026
Same author

Trends in Gestational Diabetes Identified through Universal Screening: A Population-Based Observational Study.

BJOG : an international journal of obstetrics and gynaecology·2026
Same author

Age- and cognitive load-related variability and entropy of gait: integrating coefficient of variation, median absolute deviation, and permutation entropy of spatiotemporal parameters into the Semmelweis Study gait assessment framework.

GeroScience·2026
Same author

Comorbidity indices in observational studies on cardiovascular risk.

Open heart·2026
Same author

Changes of the cardiac electrical cycle in type 1 diabetes during hypoglycaemia - a prospective observational study.

Frontiers in endocrinology·2026
Same author

Comorbidity indices in observational studies on cancer risk.

Acta oncologica (Stockholm, Sweden)·2026

Related Experiment Video

Updated: Apr 13, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
03:07

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

532

Obesity attenuates gender differences in cardiovascular mortality.

Xin Song1,2, Adam G Tabák3,4, Björn Zethelius5,6

  • 1Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. xin.song@helsinki.fi.

Cardiovascular Diabetology
|May 1, 2015
PubMed
Summary

Men face higher cardiovascular disease (CVD) mortality than women, particularly with increasing obesity. This gender gap in CVD risk narrows slightly in obese individuals, suggesting complex interactions between obesity, gender, and mortality.

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K
Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
03:35

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

810

Related Experiment Videos

Last Updated: Apr 13, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
03:07

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

532
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K
Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
03:35

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

810

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) remains a leading cause of mortality globally.
  • Obesity is a significant risk factor for CVD, but its impact may differ by gender.
  • Understanding gender-specific CVD mortality risks associated with obesity is crucial for targeted prevention strategies.

Purpose of the Study:

  • To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender.
  • To analyze the association between various anthropometric measures of obesity and CVD mortality.
  • To investigate potential gender differences in CVD mortality across obesity categories.

Main Methods:

  • Analysis of data from 11 prospective cohorts across four European countries.
  • Inclusion of 23,629 men and 21,965 women aged 24-99 years with a median follow-up of 7.9 years.
  • Estimation of hazards ratios (HR) for CVD mortality using Cox proportional hazards models based on body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR).

Main Results:

  • Men exhibited higher CVD mortality than women across all body mass index (BMI) categories.
  • Increased BMI, waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were associated with significantly higher CVD mortality in both genders.
  • The gender disparity in CVD mortality was less pronounced among obese individuals, with statistically significant interactions noted between gender and WC/WHtR.

Conclusions:

  • Men consistently experience higher cardiovascular disease (CVD) mortality compared to women, irrespective of obesity levels.
  • Obesity is linked to increased CVD mortality in both genders, with men showing a more pronounced risk at higher obesity levels.
  • The attenuated gender difference in CVD mortality among obese individuals warrants further investigation into underlying biological and lifestyle factors.