Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
Genetic Variation01:25

Genetic Variation

1.6K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.6K
The Evidence for Evolution02:55

The Evidence for Evolution

50.7K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
50.7K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

66.3K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
66.3K
Variability: Analysis01:11

Variability: Analysis

720
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
720
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

10.1K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological Variation of Natriuretic Peptides and Other Cardiovascular Disease-Related Biomarkers: A Systematic Review and Meta-analysis.

Clinical chemistry·2026
Same author

Reducing hemolysis in emergency departments: effectiveness of BD Barricor™ low-vacuum tubes.

Advances in laboratory medicine·2026
Same author

Thyroid hormone profile and biological variation in a population of athletes during an entire sport season.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Patient Data and refineR for Efficient Monitoring and Verifying Laboratory Reference Intervals: A Practical Approach.

Annals of laboratory medicine·2026
Same author

Applying the OMOP common data model to laboratory data: challenges, opportunities, and implications - a use case in biological variation research.

Clinical chemistry and laboratory medicine·2026
Same author

Impact of six sigma estimated using the Schmidt-Launsbyn vs. the Westgard equation in the Spanish type I EQA program.

Advances in laboratory medicine·2025
Same journal

Ethical evaluation of reflex and reflective testing in conformity with ISO 15189:2022 at the value-based laboratory medicine era.

Clinical chemistry and laboratory medicine·2026
Same journal

Emerging blood-based diagnostic strategies for tuberculosis.

Clinical chemistry and laboratory medicine·2026
Same journal

Homocitrulline and 3-year mortality in older hospitalised adults: an exploratory study.

Clinical chemistry and laboratory medicine·2026
Same journal

Impact of age partitioning on classification discordance in pediatric ferritin reference intervals.

Clinical chemistry and laboratory medicine·2026
Same journal

National implementation of LOINC: translation methodology and experience from the Polish laboratory terminology standardization project.

Clinical chemistry and laboratory medicine·2026
Same journal

Harmonization of measurement units: mission impossible or ethical imperative?

Clinical chemistry and laboratory medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 13, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.5K

Rationale for using data on biological variation.

Carmen Ricós, Virtudes Álvarez, Carmen Perich

    Clinical Chemistry and Laboratory Medicine
    |May 1, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Biological variation (BV) data enhances laboratory management and patient monitoring. More international studies and criteria are needed to expand the use of BV estimates in laboratory medicine.

    More Related Videos

    Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
    10:08

    Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

    Published on: August 12, 2019

    17.8K
    In Vivo Modeling of the Morbid Human Genome using Danio rerio
    12:31

    In Vivo Modeling of the Morbid Human Genome using Danio rerio

    Published on: August 24, 2013

    21.6K

    Related Experiment Videos

    Last Updated: Apr 13, 2026

    In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
    06:41

    In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

    Published on: August 20, 2019

    14.5K
    Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
    10:08

    Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

    Published on: August 12, 2019

    17.8K
    In Vivo Modeling of the Morbid Human Genome using Danio rerio
    12:31

    In Vivo Modeling of the Morbid Human Genome using Danio rerio

    Published on: August 24, 2013

    21.6K

    Area of Science:

    • Laboratory Medicine
    • Clinical Chemistry
    • Biostatistics

    Background:

    • Biological variation (BV) data is crucial for laboratory management.
    • The biological variation database offers valuable insights for clinical laboratories.
    • Understanding BV is essential for interpreting patient results accurately.

    Purpose of the Study:

    • To assess the usability of biological variation (BV) estimates using existing database data.
    • To demonstrate practical applications of BV data in laboratory medicine through real-world examples.
    • To highlight the importance of BV in setting analytical performance specifications and quality control.

    Main Methods:

    • Utilizing data from the biological variation (BV) database.
    • Analyzing BV estimates for healthy individuals and patients.
    • Applying BV data to establish analytical performance specifications and quality control parameters.

    Main Results:

    • BV data is effectively used in quality control software and external quality assurance reports.
    • Significant differences in intra-individual variation (CVI) exist between healthy and pathological states.
    • Limited data availability for many analytes necessitates further research.

    Conclusions:

    • Biological variation data is a valuable tool for laboratory management and patient monitoring.
    • International collaboration and standardized criteria are needed for BV estimation and evaluation.
    • Further research and data collection are encouraged to enhance the application of BV in laboratory medicine.