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AIDS with disseminated histoplasmosis.
R A Martin1, T Williams, N Montalto
1Department of Family Medicine, College of Medicine, Ohio State University, Columbus 43210.
The Journal of Family Practice
|December 1, 1989
Summary
Acquired immunodeficiency syndrome (AIDS) patients with disseminated histoplasmosis require combination therapy. Amphotericin B followed by lifelong ketoconazole is the best treatment to prevent relapse.
Area of Science:
- Infectious Diseases
- Immunology
Background:
- Acquired immunodeficiency syndrome (AIDS) is an immune deficiency disease.
- Histoplasmosis is a fungal infection that can disseminate in immunocompromised individuals.
Observation:
- Two cases of AIDS and disseminated histoplasmosis in Ohio are described.
- One patient presented with disseminated histoplasmosis as their first AIDS-related illness.
- The second patient had severe pharyngitis without pulmonary symptoms.
Findings:
- Amphotericin B monotherapy is insufficient for eradicating histoplasmosis in AIDS patients.
- Optimal treatment involves a full course of amphotericin B followed by long-term ketoconazole.
- This combination therapy is crucial for preventing relapse.
Implications:
- Healthcare providers in specific US states and Puerto Rico should maintain high vigilance for this dual diagnosis.
- Early recognition and appropriate treatment are vital for managing disseminated histoplasmosis in AIDS patients.