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Association between vasoactive-inotropic score and mortality in pediatric septic shock

A Haque1, N R Siddiqui, O Munir

  • 1Departments of Pediatrics and Child Health, and *Emergency Medicine, Aga Khan University Hospital, Karachi, Pakistan. Correspondence to: Dr Anwarul Haque, Associate Professor, Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan. anwar.haq@aku.edu.

Indian Pediatrics
|May 2, 2015
PubMed

Insights

A high Vasoactive Inotrope Score (VIS) in children with septic shock indicates a greater risk of mortality. This finding highlights the importance of monitoring VIS in pediatric intensive care units.

Area of Science:

  • Pediatric critical care medicine
  • Pediatric cardiology
  • Pediatric infectious diseases

Background:

  • Septic shock in children is a life-threatening condition requiring intensive management.
  • Fluid-refractory septic shock necessitates the use of vasoactive medications.
  • The Vasoactive Inotrope Score (VIS) quantifies the need for these medications.

Purpose of the Study:

  • To investigate the correlation between the Vasoactive Inotrope Score (VIS) and mortality rates in pediatric patients experiencing fluid-refractory septic shock.

Main Methods:

  • A retrospective analysis was conducted on 71 children (1 month to 16 years) admitted with fluid-refractory septic shock.
  • Patients were categorized into High VIS (Group-H) and Low VIS (Group-L) groups using a cutoff value of 20.
  • Data were collected from a two-year period in a pediatric intensive care unit.

Main Results:

  • The majority of children (73%) were in the Low VIS group.
  • A significantly higher mortality rate was observed in the High VIS group (100%) compared to the Low VIS group (44%).

Conclusions:

  • Elevated Vasoactive Inotrope Score (VIS) in pediatric septic shock is strongly associated with increased mortality.
  • VIS may serve as a critical prognostic indicator in children with severe sepsis.
Abstract

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