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Updated: Apr 13, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Analysis of association between sunscreens use and risk of malignant melanoma
Fang Xie1, Tingting Xie2, Qi Song3
1Department of Dermatology, Chinese PLA General Hospital Beijing 100853 ; Medical College of PLA Beijing 100853, P. R. China.
Background:
Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma.
Methods:
Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test.
Results:
Twenty-one studies including 7150 malignant melanoma cases about sunscreens use with the risk of malignant melanoma were included in this meta-analysis. The combined relative risk (RR) of malignant melanoma associated with sunscreens use was 1.145 (95% CI=0.912-1.438). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found.
Conclusions:
Our analysis indicated that sunscreens use is not associated with the risk of malignant melanoma.
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