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In situ cross-linked matrix tablets for sustained salbutamol sulfate release - formulation development by statistical
Jadupati Malakar1, Krishnagopal Das1, Amit Kumar Nayak2
1Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India.
Polimery W Medycynie
|May 2, 2015
Summary
This study developed in situ cross-linked matrix tablets for sustained salbutamol sulfate release using natural polymers. The optimized tablets demonstrated prolonged drug release, potentially improving patient compliance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Natural polymers are increasingly utilized in designing sustained-release drug delivery systems.
- Matrix tablets offer a promising approach for controlled drug release.
Purpose of the Study:
- To develop and optimize in situ cross-linked matrix tablets for sustained salbutamol sulfate release.
- To investigate the impact of formulation variables on drug release and tablet properties.
Main Methods:
- Salbutamol sulfate matrix tablets were prepared using direct compression.
- Response surface methodology with a 3^2 factorial design was employed for optimization.
- Analysis of drug content, weight variation, hardness, and in vitro drug release kinetics.
Main Results:
- All developed in situ cross-linked matrix tablets exhibited acceptable drug content, weight uniformity, and hardness.
- Prolonged sustained release of salbutamol sulfate was observed over a 6-hour period.
- Formulation parameters significantly influenced tablet properties and drug release profiles.
Conclusions:
- The developed in situ cross-linked matrix tablets offer a viable alternative to conventional salbutamol sulfate formulations.
- These sustained-release tablets may reduce dosing frequency, thereby enhancing patient compliance.
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