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Updated: Apr 13, 2026

Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques
Published on: January 12, 2024
The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site
Yongsheng Shi1, James L Manley2
1Department of Microbiology and Molecular Genetics, School of Medicine, University of California at Irvine, Irvine, California 92697, USA; jlm2@columbia.edu yongshes@uci.edu.
Abstract:
The key RNA sequence elements and protein factors necessary for 3' processing of polyadenylated mRNA precursors are well known. Recent studies, however, have significantly reshaped current models for the protein-RNA interactions involved in poly(A) site recognition, painting a picture more complex than previously envisioned and also providing new insights into regulation of this important step in gene expression. Here we review the recent advances in this area and provide a perspective for future studies.
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